This summary provides an overview of the chapter titled "Natural Iron Chelators as Potential Therapeutic Agents for the Treatment of Iron Overload Diseases" published in the book "Trace Elements and Their Effects on Human Health and Diseases." The chapter explores the potential of natural iron chelators as therapeutic agents for managing iron overload diseases.
Iron Overload Diseases:
It highlights iron overload diseases, conditions characterized by excessive accumulation of iron in the body. These diseases, including hereditary hemochromatosis and transfusional iron overload, can lead to tissue damage, organ dysfunction, and various health complications.
Role of Iron Chelators:
The study discusses the role of iron chelators in managing iron overload diseases. Iron chelators are compounds that bind to excess iron, forming stable complexes that can be excreted from the body. Chelation therapy aims to reduce iron burden and prevent or mitigate iron-related damage.
Natural Iron Chelators:
The chapter focuses on natural iron chelators derived from plant sources, including polyphenols, flavonoids, and other bioactive compounds. These natural compounds possess chelating properties and have been investigated for their potential therapeutic applications in managing iron overload diseases.
Therapeutic Potential:
The study explores the therapeutic potential of natural iron chelators in iron overload diseases. It discusses their ability to bind and remove excess iron, their antioxidant properties, and their potential to modulate iron-related signaling pathways. These properties make them promising candidates for therapeutic interventions.
Efficacy and Safety:
The chapter discusses the efficacy and safety considerations of natural iron chelators. It examines the results of preclinical and clinical studies, highlighting their potential benefits in reducing iron burden and improving iron-related complications. Additionally, it addresses the safety profile and potential side effects of natural iron chelators.
Conclusion:
The chapter emphasizes the potential of natural iron chelators as therapeutic agents for the treatment of iron overload diseases. Their ability to bind and remove excess iron, along with their antioxidant and modulatory properties, make them attractive candidates for further research and development. Continued studies are needed to explore their efficacy, safety, and optimal dosing regimens to establish their clinical utility in managing iron overload diseases.